Get the MovieNight app
Add it to your home screen — faster & full screen
Copperheart Entertainment
Dark Castle Entertainment
Gaumont
Senator Film
Not part of a collection.
She's not human...not entirely.
Elsa and Clive, two young rebellious scientists, defy legal and ethical boundaries and forge ahead with a dangerous experiment: splicing together human and animal DNA to create a new organism. Named "Dren", the creature rapidly develops from a deformed female infant into a beautiful but dangerous winged human-chimera, who forges a bond with both of her creators - only to have that bond turn deadly.
CinemaSerf
Oct 26, 2022 · via TMDB
"Clive" (Adrien Brody) and "Elsa" (Sarah Polley) are a couple of genetic engineers charged by David Hewlett's "Barlow" with discovering an important gene that could lead to huge advances in medical science. Using a mix of human and animal DNA that have varying degrees of success before the evolution of a creature "Dren" (Delphine Chanéac) that develops more human attributes - as well as a tail with a stinger and the ability to grow wings. As we progress through this frankly rather disturbing story, we discover that "Elsa" quite literally has skin in the game as they must both seek to protect their creation from not just their employers but from her increasingly violent and lustful tendencies. I was quite interested in the underlying premise but the execution here is really poor. I never did really get why Brody was ever successful in the first place and here there is no chemistry between him and Polley; the storyline which could have been challenging and thought-provoking instead borders on the absurdly far-fetched and the ending couldn't really come quick enough as we really do struggle to reach any sort of a satisfactory conclusion - either from a personal or a scientific perspective. It does highlight the dangers of unfettered scientific experimentation but sadly in no more an entertaining fashion that we have seen many times before - more enjoyably - from Hammer Studios!
John Chard
Dec 2, 2018 · via TMDB
Brundledren! Splice is a tricky picture to evaluate, for its ideas are superb. One could argue that it brings a new petri dish full of meddling scientists facing the consequences of their actions, while conversely it justifiably feels like a Cronenberg knock-off. Psychological discord is in abundance, with its slants on skew-whiff parenting giving the pic a dark fascination, and as unpleasant as the male fantasy angle is, it does hold a morbid interest factor. Yet come the final third the makers let things run away from them, the bonkers dangers of tampering with science giving way to daft schlock, even managing to be distasteful in the process - while the finale is a weak attempt at a "TBC" cliff hanger. Lead cast members are turning in good perfs. Adrien Brody and Sarah Polley as the meddling science couple hold court well, and Delphine Chaneac as the Chimera splicer of the piece really nails all the various emotional strands required for a tricky role. Director Vincenzo Natali has shown with Cube and Cypher he has something to offer the horror/sci-fi splinters of film, but this is a mixed bag. A film of great ideas let down by overheating the plot for shock values, while the levity inserted into the play is misguided and damaging for dramatic worth. 6/10
Andres Gomez
Nov 26, 2014 · via TMDB
The FX is OK and the uneasiness and thrill is always there but the script is stereotypical, weak and full of holes.
User reviews courtesy of TMDB.
Google Play Movies
YouTube
Google Play Movies
YouTube
Adrien Brody
Clive
Sarah Polley
Elsa
Delphine Chanéac
Dren
David Hewlett
Barlow
Abigail Chu
Young Dren
Stephanie Baird
Elsa / PD
Brandon McGibbon
Gavin
Amanda Brugel
Melinda Finch
Simona Măicănescu
Joan Chorot
Tetsuo Nagata
Director of Photography
Plato Fountidakis
Stunt Coordinator
Christopher Cordell
Stunt Double
Hubert Boorder
Stunt Double
Cynthia Amsden
Unit Publicist
Vincenzo Natali
Director
Constance Demontoy
Casting
Jason Knight
Casting
John Buchan
Casting
John Papsidera
Casting
Don Murphy
Executive Producer
Franck Chorot
Executive Producer
Guillermo del Toro
Executive Producer
Joel Silver
Executive Producer
Sidonie Dumas
Executive Producer
Marty Dejczak
Location Manager
Steven Hoban
Producer
Janice Ierulli
Dialogue Editor
Cyrille Aufort
Original Music Composer
David Rose
Sound Designer
Laurent Kossayan
Supervising Sound Editor
Ian Hunter
Visual Effects Supervisor
Pierre Buffin
Visual Effects Supervisor
Vincenzo Natali
Screenplay
Vincenzo Natali
Story
Jan 22, 2010
Sundance Film Festival
May 30, 2010
Seattle International Film Festival
Jun 2, 2010
Los Angeles, California
Jun 4, 2010
Oct 5, 2010
DVD
© 2025-2026 MovieNight. All rights reserved.
Versus
Sign in to play →
The Stranglers - Live '78, SF
1978
Saddle Leather Law
1944
Sign in to vote
Battle your watched movies head-to-head
Community Top Movies
Evil Dead II
1987 · 14 wins
The Dark Knight
2008 · 14 wins
Halloween
1978 · 13 wins
Final Destination
2000 · 12 wins
Halloween II
1981 · 11 wins
Trivia
Leaderboard →Playing as a guest — sign in to save your score and rank on the leaderboard.
Movie Trivia
Guess the movie from a clue — tagline, plot, cast and more. Pick from four posters.
What movie experience do you prefer?
What is your favorite movie genre?
Versus
Sign in to play →
The Stranglers - Live '78, SF
1978
Saddle Leather Law
1944
Sign in to vote
Battle your watched movies head-to-head
Community Top Movies
Evil Dead II
1987 · 14 wins
The Dark Knight
2008 · 14 wins
Halloween
1978 · 13 wins
Final Destination
2000 · 12 wins
Halloween II
1981 · 11 wins
Trivia
Leaderboard →Playing as a guest — sign in to save your score and rank on the leaderboard.
Movie Trivia
Guess the movie from a clue — tagline, plot, cast and more. Pick from four posters.
What movie experience do you prefer?
What is your favorite movie genre?
We use essential cookies to run MovieNight, plus analytics (Google Analytics) and advertising (Google AdSense) cookies. By continuing to browse, you agree to this — or click No and we won't. See our Terms & Privacy Policy to learn more.